Thesis

1. Oguchi O, Mori A, Kobayashi Y, Horiuchi A, Nikaido T, Fujii S.

   Prediction of histopathologic features and proliferative activity of uterine leiomyoma by magnetic resonance imaging prior to GnRH analogue therapy: correlation between T2-weighted images and effect of GnRH analogue. J Obstet Gynaecol (Tokyo 1995). 1995 Apr;21(2):107-17.

2. Toki T, Horiuchi A, Li SF, Nakayama K, Silverberg SG, Fujii S.

   Proliferative activity of postmenopausal endometriosis: a histopathologic and immunocytochemical study. Int J Gynecol Pathol. 1996 Jan;15(1):45-53.

3. Kobayashi Y, Zhai YL, Iinuma M, Horiuchi A, Nikaido T, Fujii S.

   Effects of a GnRH analogue on human smooth muscle cells cultured from normal myometrial and from uterine leiomyomal tissues. Mol Hum Reprod. 1997 Feb;3(2):91-9.

4. Horiuchi A, Nikaido T, Ito K, Zhai Y, Orii A, Taniguchi S, Toki T, Fujii S.

   Reduced expression of calponin h1 in leiomyosarcoma of the uterus. Lab Invest. 1998 Jul;78(7):839-46.

5. Horiuchi A, Osada R, Nakayama K, Toki T, Nikaido T, Fujii S.

   Ovarian yolk sac tumor with endometrioid carcinoma arising from endometriosis in a postmenopausal woman, with special reference to expression of alpha-fetoprotein, sex steroid receptors, and p53. Gynecol Oncol. 1998 Aug;70(2):295-9.

6. Horiuchi A, Nikaido T, Ya-Li Z, Ito K, Orii A, Fujii S.

   Heparin inhibits proliferation of myometrial and leiomyomal smooth muscle cells through the induction of alpha-smooth muscle actin, calponin h1 and p27. Mol Hum Reprod. 1999 Feb;5(2):139-45.

7. Horiuchi A, Nikaido T, Taniguchi S, Fujii S.

   Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma. J Natl Cancer Inst. 1999 May 5;91(9):790-6.

8. Toki T, Horiuchi A, Ichikawa N, Mori A, Nikaido T, Fujii S.

   Inverse relationship between apoptosis and Bcl-2 expression in syncytiotrophoblast and fibrin-type fibrinoid in early gestation. Mol Hum Reprod. 1999 Mar;5(3):246-51.

9. Zhai YL, Nikaido T, Orii A, Horiuchi A, Toki T, Fujii S.

   Frequent occurrence of loss of heterozygosity among tumor suppressor genes in uterine leiomyosarcoma. Gynecol Oncol. 1999 Dec;75(3):453-9.

10. Horiuchi A, Nikaido T, Yoshizawa T, Itoh K, Kobayashi Y, Toki T, Konishi I, Fujii S.

    HCG promotes proliferation of uterine leiomyomal cells more strongly than that of myometrial smooth muscle cells in vitro. Mol Hum Reprod. 2000 Jun;6(6):523-8.

11. Horiuchi A, Nikaido T, Mitsushita J, Toki T, Konishi I, Fujii S.

    Enhancement of antitumor effect of bleomycin by low-voltage in vivo electroporation: a study of human uterine leiomyosarcomas in nude mice. Int J Cancer. 2000 Nov 15;88(4):640-4.

12. Nakayama K, Toki T, Zhai YL, Lu X, Horiuchi A, Nikaido T, Konishi I, Fujii S.

    Demonstration of focal p53 expression without genetic alterations in endometriotic lesions. Int J Gynecol Pathol. 2001 Jul;20(3):227-31.

13. Shiozawa T, Horiuchi A, Kato K, Obinata M, Konishi I, Fujii S, Nikaido T.

    Up-regulation of p27Kip1 by progestins is involved in the growth suppression of the normal and malignant human endometrial glandular cells. Endocrinology. 2001 Oct;142(10):4182-8.

14. Shiozawa T, Itoh K, Horiuchi A, Konishi I, Fujii S, Nikaido T.

    Down-regulation of estrogen receptor by the methylation of the estrogen receptor gene in endometrial carcinoma. Anticancer Res. 2002 Jan-Feb;22(1A):139-43.

15. Horiuchi A*, Imai T, Shimizu M, Oka K, Wang C, Nikaido T, Konishi I.

    Hypoxia-induced changes in the expression of VEGF, HIF-1 alpha and cell cycle-related molecules in ovarian cancer cells. Anticancer Res. 2002 Sep-Oct;22(5):2697-702. (* corresponding author)

16. Horiuchi A, Itoh K, Shimizu M, Nakai I, Yamazaki T, Kimura K, Suzuki A, Shiozawa I, Ueda N, Konishi I.

    Toward understanding the natural history of ovarian carcinoma development: a clinicopathological approach. Gynecol Oncol. 2003 Mar;88(3):309-17.

17. Shimizu T, Nikaido T, Gomyo H, Yoshimura Y, Horiuchi A, Isobe K, Ebara S, Takaoka K. Electrochemotherapy for digital chondrosarcoma. J Orthop Sci. 2003;8(2):248-51.

18. Horiuchi A*, Imai T, Wang C, Ohira S, Feng Y, Nikaido T, Konishi I.

    Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Lab Invest. 2003 Jun;83(6):861-70. (* corresponding author)

19. Imai T, Horiuchi A*, Wang C, Oka K, Ohira S, Nikaido T, Konishi I.

    Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol. 2003 Oct;163(4):1437-47. (* corresponding author)

20. Wang C, Horiuchi A*, Imai T, Ohira S, Itoh K, Nikaido T, Katsuyama Y, Konishi I.

    Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the BRCA1 gene. J Pathol. 2004 Feb;202(2):215-23. (* corresponding author)

21. Kato K, Shiozawa T, Mitsushita J, Toda A, Horiuchi A, Nikaido T, Fujii S, Konishi I.

    Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas. Hum Pathol. 2004 Jan;35(1):55-60.

22. Ohira S, Itoh K, Shiozawa T, Horiuchi A, Ono K, Takeuchi H, Hosoda W, Konishi I.

    Ovarian non-small cell neuroendocrine carcinoma with paraneoplastic parathyroid hormone-related hypercalcemia. Int J Gynecol Pathol. 2004 Oct;23(4):393-7.

23. Imai T, Horiuchi A*, Shiozawa T, Osada R, Kikuchi N, Ohira S, Oka K, Konishi I.

    Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas. Hum Pathol. 2004 Dec;35(12):1469-76. (* corresponding author)

24. Feng YZ, Shiozawa T, Horiuchi A, Shih HC, Miyamoto T, Kashima H, Suzuki A, Nikaido T, Konishi I.

    Intratumoral heterogeneous expression of p53 correlates with p53 mutation, Ki-67, and cyclin A expression in endometrioid-type endometrial adenocarcinomas. Virchows Arch. 2005 Nov;447(5):816-22.

25. Hanaoka Y, Kato K, Ose K, Sakai M, Miyamoto T, Horiuchi A, Ito K, Shiozawa T , Kobayashi T, Konishi I.

    A successful therapy for a case of invasive uterine carcinosarcoma complicated by preoperative multiple hemorrhagic infarcts。Ｊapanese J Obstet. Gynecological Neonatal Hematology. 2006; 15; 59-65.

26. Ohira S, Ashida T, Kanai M, Horiuchi A, Konishi I.

    Immunohistochemical evaluation for the growth and invasion potentials of intermediate trophoblasts. Placenta. 2006; 27 : 9-10.

27. Kikuchi N, Horiuchi A*, Osada R, Imai T, Wang C, Chen X, Konishi I.

    Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: an important autocrine/paracrine factor in tumor progression. Cancer Sci. 2006 Oct;97(10):1061-9. (* corresponding author)

28. Osada R, Horiuchi A*, Kikuchi N, Ohira S, Ota M, Katsuyama Y, Konishi I.

    Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas. Hum Pathol. 2006 Nov;37(11):1414-25. (* corresponding author)

29. Horiuchi A*, Wang C, Kikuchi N, Osada R, Nikaido T, Konishi I.

    BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells.　Biomark Insights. 2007 Mar 2;1:49-59. (* corresponding author)

30. Chen X, Horiuchi A*, Kikuchi N, Osada R, Yoshida J, Shiozawa T, Konishi I.

    Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it’s inhibition leads to growth suppression and apoptosis. Cancer Sci. 2007 Jan;98(1):68-76. (* corresponding author)

31. Osada R, Horiuchi A*, Kikuchi N, Yoshida J, Hayashi A, Ota M, Katsuyama Y, Melillo G, Konishi I.

    Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma. Hum Pathol. 2007 Sep;38(9):1310-20. (* corresponding author)

32. Hayashi T, Shimamura Y, Saegusa T, Horiuchi A, Kobayashi Y, Hiraoka N, Kanai Y, Aburatani H, Sano K, Konishi I.

    Molecular Mechanisms of Uterine Leiomyosarcomas: Involvement of Defect in LMP2 Expression. Gene Regul Syst Bio. 2008 Jul ;22(2):297-305.

33. Horiuchi A*, Kikuchi N, Osada R, Wang C, Hayashi A, Nikaido T, Konishi I.

    Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer. Cancer Sci. 2008 Dec;99(12):2532-9. (* corresponding author)

34. Kashima H, Horiuchi A*, Uchikawa J, Miyamoto T, Suzuki A, Ashida T, Konishi I, Shiozawa T.

    Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma. Anticancer Res. 2009 Apr;29(4):1023-9. (* corresponding author)

35. Yoshida J, Horiuchi A*, Kikuchi N, Hayashi A, Osada R, Ohira S, Shiozawa T, Konishi I.

    Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression. Med Mol Morphol. 2009 Jun;42(2):82-91. (* corresponding author)

36. Miyamoto T, Horiuchi A*, Kashima H, Suzuki A, Yamada T, Kurai M, Konishi I, Shiozawa T.

    Inverse correlation between Skp2 and p27(Kip1) in normal endometrium and endometrial carcinoma. Gynecol Endocrinol. 2009 Aug 31:1-10. (* corresponding author)

37. Hayashi A, Horiuchi A*, Kikuchi N, Hayashi T, Fuseya C, Suzuki A, Konishi I, Shiozawa T.

    Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with down-regulation of E-cadherin. Int J Cancer. 2010 Sep 1;127(6):1332-46. (* corresponding author)

38. uzuki A, Horiuchi A, Oka K, Miyamoto T, Kashima H, Shiozawa T.

    Immunohistochemical detection of steroid receptor cofactors in ovarian endometriosis: involvement of down-regulated SRC-1 expression in the limited growth activity of the endometriotic epithelium.Virchows Arch. 2010 Apr; 456(4):433-41.

39. Suzuki A, Horiuchi A, Ashida T, Miyamoto T, Kashima H, Nikaido T, Konishi I, Shiozawa T.

    Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin. J Cell Mol Med. 2010 Sep;14(9):2305-17.

40. Abiko K, Mandai M, Hamanishi J, Matsumura N, Baba T, Horiuchi A, Mikami Y, Yoshioka S, Wakasa T, Shiozawa T, Konishi I.

    Oct4 expression in immature teratoma of the ovary: relevance to histologic grade and degree of differentiation.　 Am J Surg Pathol. 2010 Dec;34(12):1842-8.

41. Okamoto T, Matsumura N, Mandai M, Oura T, Yamanishi Y, Horiuchi A, Hamanishi J, Baba T, Koshiyama M, Shiozawa T, Konishi I.

    Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1. Mod Pathol. 2010 Nov 12. Epub ahead of print.

42. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kanai Y, Shiozawa T, Tonegawa S, Konishi I.

    Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma. Protein Cell. 2010 Aug;1(8):711-7.

43. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kanai Y, Shiozawa T, Tonegawa S, Konishi I

    Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma. Sarcoma. 2011:476498. Epub 2011 Mar 8.

44. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Nagase S, Ishiko O, Kanai Y, Yaegashi N, Aburatani H, Shiozawa T, Tonegawa S, Konishi I.

    Involvement of LMP2, IFN--inducuble factor, on development of uterin leiomyosarcoma. Curr. Res. In Immunology. 2011; 5:51-63.

45. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Nagase S, Ishiko O, Shiozawa T, Kanai Y, Yaegashi N, Aburatani H, Tonegawa S, Konishi I.

    Involvement of proteasome β1i subunit, LMP2, on development of uterin leiomyosarcma. N Am J Med Sci. 2011 Sep;3(9):394-9.

46. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Sudo T, Tagawa Y, Nishimura R, Ishiko O, Kanai Y, Yaegashi N, Aburatani H, Shiozawa T, Konishi I.

    Potential role of LMP2, as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy. Sci Rep. 2011;1:180. Epub 2011 Dec 5.

47. Fuseya C, Horiuchi A*, Hayash A, Suzuki A, Miyamoto T, Hayashi T, ShiozawaT.

    Involvement of pelvic inflammation-related mismatch repair abnormalities and　microsatellite instability in the malignant transformation of ovarian endometriosis. Hum Pathol. 2012 May 22. [Epub ahead of print] (* corresponding author)

48. Mitsuhashi Y, Horiuchi A, Miyamoto T, Kashima H, Suzuki A, Shiozawa T.

    Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells. Histopathology. 2012 Apr;60(5):826-37.

49. Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kasai M, Ichimura T, Sudo T, Nishimura R, Ishiko O, Shiozawa T, Kanai Y, Yaegashi N, Aburatani H, Konishi I.

    Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h1. FEBS Lett. 2012 Jun 21;586(13):1824-31. Epub 2012 May 29.

50. Horiuchi A*, Hayashi T, Kikuchi N, Hayashi A, Fuseya C, Shiozawa T, Konishi I.

    Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation free hypoxia response element (HRE) of S100A4 gene. Int J Cancer 2012 Oct 15;131(8):1755-67. doi: 10.1002/ijc.27448. Epub 2012 Mar 14. (* corresponding author)

Review

1. Horiuchi A. Konishi I.

   Possible Role of Hypoxia in Peritoneal Dissemination of Ovarian Cancer Cells: A Review TRENDS IN OVARIAN CANCER RESEARCH 2004. Chapter III, pp43-54, A. P. Bardos (Editor) Nova Science Publishers, Inc. Hauppauge NY

2. Horiuchi A. Konishi I.

   Prevention of ovarian cancer development. Nippon Rinsho. 2004 Oct;62 Suppl 10:597-600.

3. Horiuchi A. Konishi I.

   Mechanism of ovarian cancer metastasis–changes in E-cadherin expression. Nippon Rinsho. 2004 Oct;62 Suppl 10:463-6.

4. Hayashi T, Kobayashi Y, Horiuchi A, Hiraoka N, Kubota N, Kanai Y, Aburatani H, Konishi I, Sano K.

   Interferon- and cancer immunoediting: Insight from tumorigenesis of uterine leiomyosarcoma. Curr. Res. In Immunology 2007;1:33-46.

5. Hayashi T, Kobayashi Y, Horiuchi A, Hiraoka N, Kanai Y, Aburatani H, Konishi I, and Sano K.

   Molecular Mechanisms of Uterine Leiomyosarcomas: Involvement of defective LMP2 activation. J. Medical Hypotheses and Research 2008; 4：11-20.